The Polyamine Pathway in PMP: Secretion Beyond Growth
The Polyamine Pathway in PMP: Secretion Beyond Growth Single-cell RNA Sequence Analysis of Pseudomyxoma Peritonei Share This Article: Abstract Pseudomyxoma peritonei (PMP) is a rare appendiceal malignancy that produces progressive, debilitating mucin accumulation in the peritoneal cavity despite relatively low proliferative activity. This paradox suggests that PMP tumors depend on programs supporting secretion and proteostasis […]
Bina Therapeutics Publishes Preclinical Results of TRAABA24
TRAABA24 Preclinical Results Share This Article: Abstract Background: Pseudomyxoma peritonei (PMP) is a rare malignancy with limited treatment options. Mitomycin C (MMC) is a frontline chemotherapeutic used in hyperthermic intraperitoneal chemotherapy (HIPEC) due to its potent cytotoxicity via DNA cross-linking. However, its severe systemic toxicity restricts use to localized administration. TRAABA24, a lipid nanoparticle (LNP) […]
Protected: Computational Drug Discovery for Pseudomyxoma Peritonei
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